Pro-angiogenic Therapy in an Experimental Model of Vascular Ischemia

Vascular ulcers are a serious health problem and its have a prevalence between 1-3%. About 80% of these ulcers are caused by venous stasis, between 10% and 25% are of arterial origin, while 25% are of mixed origin arterial and venous. On the other hand, the diabetic foot is a complication found in 15% of diabetic patients. The ischemia in this disease is a major risk factor for the surrounding tissues that are involved in wound healing. In this sense any angiogenic stimulus, that ensures an increase in the vascularization of the damaged area, could improve the process scar in those pathologies where healing could be found in a compromising situation. Therefore, our objective in this study was to evaluate the effect of a potent angiogenic factor, Proadrenomedulin N-terminal 20 peptide (PAMP), on the healing process of excisional skin defects in an experimental model.